Rehabilitation for adults with traumatic brain injury
A systematic review and assessment of medical, economic, social and ethical aspects
Presents a comprehensive, systematic assessment of available scientific evidence for effects on health, social welfare or disability. Full assessments include economic, social and ethical impact analyses. Assessment teams include professional practitioners and academics. Before publication the report is reviewed by external experts, and scientific conclusions approved by the SBU Board of Directors.
Rehabilitation for persons with mild traumatic brain injury (TBI) and persistent post-concussion symptoms:
- Specialised brain injury rehabilitation that employs problem-solving therapy or cognitive behavioural therapy (CBT) results in less severe post-concussion symptoms and depressive symptoms, improved psychological function, increased activity and participation and quality of life, when compared to usual care (low certainty of evidence, ⊕⊕◯◯). A simple cost-effectiveness analysis indicates a cost of about 500 000 SEK per quality-adjusted life year (QALY) for the intervention, but this cost might be overestimated since it does not incorporate possible cost savings resulting from the rehabilitation.
- Specialised interdisciplinary brain injury rehabilitation results in reduced post-concussion symptoms, when compared to usual care (low certainty of evidence, ⊕⊕◯◯).
Rehabilitation for persons with moderate to severe TBI:
- As few high-quality studies were identified, it was not possible to estimate the effects of vocational rehabilitation, rehabilitation with case management/coordinator, rehabilitation in supported living, specialised inpatient rehabilitation or specialised outpatient rehabilitation (very low certainty of evidence, ⊕◯◯◯).
Experiences and perspectives of the rehabilitation process from persons with TBI:
- A synthesis of qualitative studies showed that the persons with TBI were struggling on their own with adapting in their daily lives and that family members were important in that process. They experienced limited access to rehabilitation services, and perceived the interventions they receive as neither individualised nor coordinated. Furthermore, they experienced professional and respectful treatment, as well as individualised information, as beneficial for their rehabilitation process.
Current state of research in the field:
- There is a general need for high-quality studies with control groups in this research field. Standardization of study design, treatment intensity, as well as outcome instruments and measures is needed to allow the effects of different forms of rehabilitation to be compared. It would be preferable if future studies assess the effects and costs of interventions beyond one year. Furthermore, there is a need for studies in settings directly relevant to the Swedish health care system that investigate intervention efficacity as well as individuals’ experiences of receiving rehabilitation.
The aim of the project was to assess rehabilitation interventions for adults with traumatic brain injury from medical, social, ethical and health economic perspectives.
Traumatic brain injuries (TBIs) are caused by external force or sudden movement of the head. The most common causes are falls and traffic accidents. The injuries are classified as mild, moderate or severe, based on the duration of unconsciousness and the extent of posttraumatic amnesia. TBI is the most common cause of neurological disability and has often a major impact on life for the affected persons and their family members. According to Swedish hospital data, approximately 10 000 cases are treated in inpatient care and 20 000 in outpatient care every year. Approximately 50% of TBI patients are 65 years or older.
Most persons with mild TBI (including concussions) experience full recovery within a few weeks, but up to 20% experience persistent symptoms including fatigue, headache, hypersensitivity to visual and auditory stimuli, dizziness and memory problems. Access to rehabilitation services for this group varies in Sweden, from specialised care to limited care or no interventions at all.
Persons with moderate to severe TBI typically receive individual rehabilitation from a specialised inpatient brain injury team, but rehabilitation can also take place within geriatric care. After discharge from hospital, rehabilitation is given in outpatient care according to local routines.
Systematic literature reviews were conducted in accordance with PRISMA guidelines and SBU’s standardised methods. All steps in the literature assessment were conducted by two independent reviewers, and any disagreement was resolved by discussion. Quantitative data were combined in meta-analyses when study characteristics and outcome measures were comparable. The findings from the qualitative studies were synthesised through an inductive content analysis. The certainty of evidence of quantitative results was assessed according to grading of recommendations assessment, development and evaluation (GRADE), and qualitative results were assessed with Confidence in Evidence from Reviews of Qualitative research (CERQual).
Adults (≥16 years old) with traumatic brain injury (TBI). Studies with mixed populations were accepted if the proportion of TBI patients comprised >50%.
- Specialised inpatient rehabilitation at an early stage after injury for patients with moderate to severe TBI
- Specialised outpatient rehabilitation at a later stage after injury for patients with moderate to severe TBI
- Specialised outpatient rehabilitation for patients with mild TBI and persistent residual symptoms
- Rehabilitation with case management or coordinator
- Supported living in residential homes
- Vocational rehabilitation
- Less specialised rehabilitation or no rehabilitation
- Less specialised rehabilitation or no rehabilitation
- Less specialised rehabilitation or no rehabilitation
- Rehabilitation without case manager
- Living at home or other forms of living
- Other forms of rehabilitation or no rehabilitation
- Activity and participation
- Quality of life
Health economic studies
Population, Interventions, and Comparison: Same as for quantitative studies
Outcome: Resource use, costs and cost-effectiveness
Population: Same as for quantitative studies
Phenomena of Interest: Experiences of the rehabilitation process and health care contacts
Context: Hospital and at home
Quantitative studies: Randomised controlled trials (RCT) or non-randomised controlled studies of interventions (NRSI).
Health economic studies: Relevant study designs included cost studies, comparative studies of resource use, and economic evaluations, including modelling studies.
Qualitative studies: Studies with qualitative design exploring patients’ experiences and perspectives
Systematic reviews were included if inclusion and exclusion criteria were matched by our stated criteria.
Language: English, Swedish, Norwegian, or Danish.
Search period: From 1990 or 2000 (depending on intervention) and onwards. Final search: March 2019.
Databases searched: Cochrane Controlled Register of Trials (Central), PubMed (NLM), EMBASE (Elsevier), CINAHL (EBSCO), PsycINFO (EBSCO), SocINDEX.
Client/patients involvement: Yes
In total, 19 RCTs, 12 NRSIs, 10 qualitative and 3 health economic studies were included in the report (see flow charts).
Effects of the rehabilitation interventions
The results from the quantitative studies assessing the interventions’ effects on health and quality of life are summarised in Table 2. The six initial research questions resulted in 15 unique comparisons. Results favouring the intervention group were seen from specialized brain injury rehabilitation for persons with persistent post-concussion symptoms after mild TBI, when compared to usual care (low certainty of evidence). For all other comparisons, the results had very low certainty of evidence, which means that it was not possible to assess the effects of these interventions.
Health economic assessment
The systematic literature review resulted in three studies that fulfilled the eligibility and quality criteria; these studies only addressed partial aspects of the research questions. A study from the US compared telephone-based problem-solving therapy to usual care in a military health care setting. A Dutch study analysed costs for supported living one year before and one year after the intervention. Finally, an economic evaluation from the UK compared specialised vocational rehabilitation to usual care.
A simple cost-effectiveness analysis was conducted for specialized brain injury rehabilitation consisting of telephone-based problem-solving therapy, which resulted in a cost of around 500 000 SEK per QALY. It is possible that the costs are overestimated, since the calculation does not incorporate possible cost savings resulting from the rehabilitation. Whether or not the intervention should be considered cost-effective depends on what cost decision-makers deem appropriate in relation to the effect in this particular patient population.
Experiences and perspectives on the rehabilitation
The systematic review of qualitative research resulted in 10 studies, for which the findings were synthesised into three main categories. The synthesis showed that the persons with TBI were struggling on their own with adapting in their daily lives and that family members were important in that process. They experienced limited access to rehabilitation services, and perceived the interventions they received as neither individualised nor coordinated. Furthermore, they experienced professional and respectful treatment, as well as individualised information, as beneficial for their rehabilitation process.
Table 1. Overview of findings regarding the effects of the interventions. Only main groups of outcomes are shown. All results with low certainty of evidence were in favour of the intervention.
|Research question||Intervention||Comparison||Outcome (certainty of evidence)|
|Function||Activity and participation||Quality of life||Mortality|
|CBT = Cognitive behavioural therapy, VR = Vocational rehabilitation|
|Specialised inpatient rehabilitation, moderate to severe TBI||Specialised inpatient rehabilitation||Less specialised rehabilitation||Very low ⊕◯◯◯||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies|
|Specialised outpatient rehabilitation, moderate to severe TBI||CBT||Usual care||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies||No studies|
|Multidisciplinary outpatient rehabilitation||Usual care||Very low ⊕◯◯◯||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies|
|Specialised outpatient rehabilitation, mild TBI||CBT or problem-solving therapy||Usual care||Low ⊕⊕◯◯||Low ⊕⊕◯◯||Low ⊕⊕◯◯||No studies|
|CBT||Counselling||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies||No studies|
|Interdisciplinary rehabilitation||Usual care||Low ⊕⊕◯◯||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies|
|Rehabilitation with coordinator||Case management||Without case management||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Peer mentoring||Without peer mentoring||Very low ⊕◯◯◯||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies|
|Resource facilitation||Without resource facilitation||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Supported living||Residential living + rehabilitation||Living at home + rehabilitation||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Transitional living + rehabilitation||Living at home + rehabilitation||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Vocational rehabilitation (VR)||Virtual reality-based VR||Psychoeducation||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies||No studies|
|Individual VR||VR in groups||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Goal-directed, environmentfocused outpatient VR||Goal-directed, environmentfocused homebased VR||No studies||Very low ⊕◯◯◯||No studies||No studies|
|Specialised VR||Usual care||Very low ⊕◯◯◯||Very low ⊕◯◯◯||Very low ⊕◯◯◯||No studies|
Ethical and societal aspects
Persons with traumatic brain injury may have impaired capacity to make informed decisions and to make their own voice heard. This means that their autonomy is reduced, and they may be dependent on the help from family members or health care staff. Unstructured care pathways involving many different care givers in combination with the individuals’ complex rehabilitation needs and vulnerable situation, amplifies the importance of adequate support, information and coordination.
It is necessary for the health care system to provide various forms of rehabilitation interventions in order to meet patients’ individual needs. More research is needed, however, in order to conclude on which interventions that are the most effective, and in order to make health economic assessments preceding priority decisions.
It is important to acknowledge aspects related to equity and justice regarding the distribution of rehabilitation interventions, where the patient’s geographical residence, age and ability to work may impact on the access to rehabilitation. Presence or absence of family members may also have influence on the patient’s access to support and services.
It should be noted that very low certainty of evidence does not imply that an intervention lacks effect, but rather that its effect has not been sufficiently researched. This assessment has identified several scientific knowledge gaps where there is a substantial need for further research. As there was an extensive heterogeneity across the included studies regarding design, treatment intensity, outcomes and instruments, it is desirable for the field to strive for improved consistency in design and reporting.
It is also important to acknowledge that the assessment did not target rehabilitation interventions that focus on treating single symptoms. Therefore, there are several rehabilitation forms that are not included in the report.
The full report in Swedish
The full report "Rehabilitering för vuxna med traumatisk hjärnskada" (in Swedish)
Moller MC, Lexell J, Wilbe Ramsay K. Effectiveness of specialized rehabilitation after mild traumatic brain injury: A systematic review and meta-analysis. Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine. 2021;53(2):jrm00149. Read abstract
- Lina Bunketorp Käll, Sahlgrenska University Hospital, Gothenburg, Sweden
- Jan Lexell, Uppsala University, Sweden
- Maria Larsson Lund, Luleå University, Sweden
- Marika Möller, Danderyd University Hospital, Stockholm, Sweden
- Maud Stenberg, Norrland University Hospital, Umeå, Sweden
- Thomas Strandberg, University of Örebro, Sweden
- Karin Wilbe Ramsay, Project Manager, email@example.com
- Agneta Pettersson, Assistant Project Manager
- Ann Kristine Jonsson, Information Specialist
- Elisabeth Gustafsson, Project Administrator
- Jenny Berg, Health Economist (from May 2019)
- Naama Kenan Modén, Assistant Project Manager
- Pia Johansson, Health Economist (to April 20)
Internal Reviewer from SBU´s Scientific Advisory Board
Britt-Marie Stålnacke, Umeå University, Sweden
- Cecilie Røe, Oslo University Hospital, Norway
- Gunilla Eriksson, Uppsala University, Sweden
- Olli Tenovuo, Turku University Hospital, Finland
Rebecca Silverstein, SBU
Flow charts of included studies
Figure 4 Flow chart of the literature review for the three research questions relating to specialised brain injury rehabilitation compared to less specialised interventions. A common literature search was made for the three research questions. Two of the included articles contained data from the same randomised study. Studies with critical risk of bias were excluded. NRSI = Non-randomised study of intervention; RCT = Randomised controlled trial.
Figure 4.16 Flow chart of the literature review regarding Coordinator or Case management. NRSI = Non-randomised study of intervention; RCT = Randomised controlled trial.
Figure 4.17 Flow chart of the literature review regarding rehabilitation in supported living. NRSI = Non-randomised study of intervention; RCT = Randomised controlled trial.
Figure 4.18 Flow chart of the literature review regarding vocational rehabilitation. NRSI = Non-randomised study of intervention; RCT = Randomised controlled trial.
Figure 5.1 Flow chart of the Health economic literature review.
Figure 6.1 Flow chart of the literature review on the intervention Experiences and perceptions of rehabilitation.
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