Management and treatment of extravasation

When a solution is administered intravenously (infusion) to the body, it can leak outside the blood vessel into the surrounding tissue. This so-called extravasation may not only cause discomfort or pain, but also tissue irritation and damage. Different types of management strategies and treatments can be used to prevent, or limit, tissue damage and other negative consequences from extravasation.

SBU Enquiry Service

Consists of structured literature searches to highlight studies that can address questions received by the SBU Enquiry Service from Swedish healthcare or social service providers. We assess the risk of bias in systematic reviews and when needed also quality and transferability of results in health economic studies. Relevant references are compiled by an SBU staff member, in consultation with an external expert when needed.

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Question

What systematic reviews are there on non-invasive treatment of extravasation of intravenous infusions?

Identified literature

No relevant systematic review was identified.

Published: Report no: ut202210 Registration no: SBU 2021/689

Literature search

Embase via Elsevier 18 February 2022

Title: Extravasation
The final search result, usually found at the end of the documentation, forms the list of abstracts.

/de = Term from the EMTREE controlled vocabulary; /exp = Includes terms found below this term in the EMTREE hierarchy; /mj = Major Topic; :ab = Abstract; :au = Author; :ti = Article Title; :ti,ab = Title or abstract; * = Truncation; ' ' = Citation Marks; searches for an exact phrase; NEAR/n = Requests terms that are within 'n' words of each other in either direction; NEXT/n = Requests terms that are within 'n' words of each other in the order specified
Search termsItems found
Population: Extravasation
1. 'extravasation'/exp 13,110
2. extravasa*:ti,ab,kw 27,686
3. ('infiltrat*' NEAR/2 ('intravenous' OR 'iv' OR 'infus*' OR 'catheter*' OR 'cannula*' OR 'piv')):ti,ab,kw 500
4. (('infiltrat*' OR 'infus*' OR 'piv' OR 'iv' OR 'catheter*') NEXT/2 'injur*'):ti,ab,kw 1,587
5. (('intravenous*' OR 'iv' OR 'infus*' OR 'piv') NEAR/2 ('leak*' OR 'complication*')):ti,ab,kw 2,862
6. #1 OR #2 OR #3 OR #4 OR #5 37,255
Study types: Systematic reviews
7. 'systematic review'/de OR 'meta analysis'/exp OR 'cochrane database syst rev':ta OR ((systematic NEAR/3 review):ti,ab) OR 'meta analys*':ti,ab OR metaanalys*:ti,ab 564,942
Combined sets
8. #6 AND #7 414
Final result
9. #8 414

Medline via OvidSP 21 February 2022

Title: Extravasation
The final search result, usually found at the end of the documentation, forms the list of abstracts.

.ab. = Abstract; .ab,ti. = Abstract or title; .af. = All fields; Exp = Term from the Medline controlled vocabulary, including terms found below this term in the MeSH hierarchy; .sh. = Term from the Medline controlled vocabulary; .ti. = Title; / = Term from the Medline controlled vocabulary, but does not include terms found below this term in the MeSH hierarchy; * = Focus (if found in front of a MeSH-term); * or $ = Truncation (if found at the end of a free text term); .mp = Text, heading word, subject area node, title; " " = Citation Marks; searches for an exact phrase; ADJn = Positional operator that lets you retrieve records that contain your terms (in any order) within a specified number (n) of words of each other
Search termsItems found
Population: Extravasation
1. exp "Extravasation of Diagnostic and Therapeutic Materials"/ 3,831
2. "extravasa*".ti,ab,kf. 19,515
3. ('infiltrat*' adj2 ('intravenous' or 'iv' or 'infus*' or 'catheter*' or 'cannula*' or 'piv')).ti,ab,kf. 336
4. (('infiltrat*' or 'infus*' or 'piv' or 'iv' or 'catheter*') adj2 'injur*').ti,ab,kf. 1,977
5. (('intravenous*' or 'iv' or 'infus*' or 'piv') adj2 ('leak*' or 'complication*')).ti,ab,kf. 1,784
6. #1 OR #2 OR #3 OR #4 OR #5 25,399
Study types: systematic reviews and meta-analysis
7. Systematic Review.pt. OR Meta-Analysis.pt. OR Cochrane Database Syst Rev.ja. OR ((systematic adj3 review) OR "meta analys*" OR metaanalys*).ti,ab. 376,071
Combined sets
8. #6 AND #7 187
Final result
9. #8 187
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