Ketogenic diet for epilepsy

This document was published more than 2 years ago. The nature of the evidence may have changed.

Findings by SBU Alert

This is a translation of version 1, published on May 18, 1998. The latest version of this report is not available in English.

The ketogenic diet has been used for intractable epilepsy in children, and is a method that has been used sporadically for years. However, only recently has the ketogenic diet been used more systematically in Sweden. Although the treatment has been available for many years, there is little evidence about active mechanisms of diet. Several uncontrolled studies show markedly good effects in terms of seizure reduction. Known, and perhaps yet unidentified, side effects should be weighed against opportunities for improvement in a group of patients with intractable disease. Since the method requires special competence and experience, and since it is very demanding on the families, until further notice it should be used only within the framework of research projects that include systematic followup.

According to the judgment of the SBU Alert, there is currently poor* evidence about the benefits of the method for patients. Hence, it is essential to continue assessing the medical effects, side effects, and costs.

*This assessment by SBU Alert uses a 4-point scale to grade the quality and evidence of the scientific documentation. The grades indicate: (1) good, (2) moderate, (3) poor, or (4) no scientific evidence on the subject.

This summary is based on a report prepared at SBU in collaboration with Per Åmark, MD PhD, The Karolinska Hospital.

Alert is a joint effort by the Swedish Council on Technology Assessment in Health Care (SBU), the Medical Products Agency, the National Board of Health and Welfare, and the Federation of Swedish County Councils.

References

  1. Freeman J M, Vining E P G, Pillas D J, Pyzik P L, Casey J C, Kelly M T. The Ketogenic Diet: A Prospective, Intention-to-treat Evaluation of Efficacy in 150 Children,1998, submitted.
  2. Kinsman S L, Vining E P G, Quaskey S A, Mellits D, Freeman J M. Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: a Review of 58 Cases. Epilepsia 1992;33(6):1132-6.
  3. Swink D, Vining E P, Freeman J M. The Ketogenic Diet: 1997. Advances in Pediatrics 1997;44:297-329.
  4. Vining EP, Freeman JM. For the Multicenter Study of the Efficacy of Ketogenic Diet. Annals of Neurology (abstract) 1996;40:300 A.
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SBU Assessment presents a comprehensive, systematic assessment of available scientific evidence. The certainty of the evidence for each finding is systematically reviewed and graded. Full assessments include economic, social, and ethical impact analyses.

SBU assessments are performed by a team of leading professional practitioners and academics, patient/user representatives and SBU staff. Prior to approval and publication, assessments are reviewed by independent experts, SBU’s Scientific Advisory Committees and Board of Directors.

Published: 5/18/1998
Revised: 1/3/2002
Contact SBU: registrator@sbu.se
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