Cariology

Risk of bias Systematic reviews with moderate or low risk of bias Systematic reviews with high risk of bias

Methods Prevention Diagnostic Treatment

		Method
		Prevention	Diagnostics	Treament
Field	Antibacterial treatment	7 Systematic reviews with moderate or low risk of bias Coelho (2017) Okada (2016) Tang (2016) Pithon (2015) Pereira-Cenci (2013) Haps (2008) Rickard (2004)	1 Systematic reviews with moderate or low risk of bias Slot (2011)	4 Systematic reviews with moderate or low risk of bias Ornellas (2016) Walsh (2015) Riley (2013) Brazzelli (2006)
	Treatment of hypersensitive teeth	2 Systematic reviews with moderate or low risk of bias Douglas de Oliveira (2013) Yan (2013)		8 Systematic reviews with moderate or low risk of bias Machado (2018) Bae (2015) Magno (2015) West (2015) Zhu (2015) Lin (2013) Sharif (2013) Poulsen (2006)
	Detection of initial caries	4 Systematic reviews with moderate or low risk of bias Ekstrand (2018) Gomez (2013) Twetman (2013) Bader (2002)	3 Systematic reviews with moderate or low risk of bias Brouwer (2016) Gimenez (2015) Gimenez (2013)	2 Systematic reviews with moderate or low risk of bias Signori (2018) Schwendicke (2015)
	Caries removal and pulp capping	6 Systematic reviews with moderate or low risk of bias Li (2018) Tao (2017) Montedori (2016) Zhu (2015) Li (2014) Miyashita (2007)	2 Systematic reviews with moderate or low risk of bias Schwendicke (2015) Ricketts (2006)	7 Systematic reviews with moderate or low risk of bias Cianetti (2018) Didilescu (2018) Li (2018) Smail-Faugeron (2016) Schwendicke (2013) Jacobsen (2011) Olsson (2006)
	Fissure sealant	6 Systematic reviews with moderate or low risk of bias Papageorgiou (2017) Ahovuo-Saloranta (2016) Ammari (2014) Mickenautsch (2011) Yengopal (2010) Yengopal (2009)	1 Systematic reviews with moderate or low risk of bias Mickenautsch (2013)	6 Systematic reviews with moderate or low risk of bias Chatzimarkou (2018) Ahovuo-Saloranta (2017) Fumes (2017) Botton (2016) Mickenautsch (2016) Schwendicke (2015)
	Fluorides	14 Systematic reviews with moderate or low risk of bias Subbiah (2018) Hendre (2017) Hochli (2017) Sonesson (2017) Nascimento (2016) Marinho (2015) Benson (2013) dos Santos (2013) Tubert-Jeannin (2011) Walsh (2010) Wong (2010) Azarpazhooh (2008) Bonner (2006) Marinho (2004)	1 Systematic reviews with moderate or low risk of bias Marinho (2016)	11 Systematic reviews with moderate or low risk of bias Chong (2018) Oliveira (2018) Oliveira (2018) Tao (2018) Lenzi (2016) Lopatiene (2016) Wright (2014) Benson (2013) Marinho (2013) Heijnsbroek (2007) Benson (2005)
	Restorative treatment, material, success rate and filling survival	13 Systematic reviews with moderate or low risk of bias da Silva (2018) Kruly (2018) Singh (2018) Dorri (2017) Innes (2017) Raggio (2016) Pinna (2015) Reis (2015) Zhu (2015) Ricketts (2013) Yengopal (2011) Mickenautsch (2010) Mickenautsch (2010)	2 Systematic reviews with moderate or low risk of bias Shu (2018) Schwendicke (2015)	21 Systematic reviews with moderate or low risk of bias Alirezaei (2018) de Amorim (2018) Indrapriyadharshini (2018) Naumann (2018) Pires (2018) Ahmed (2016) Duangthip (2016) Magno (2016) Schenkel (2016) Schwendicke (2016) Smail-Faugeron (2016) Wang (2016) Astvaldsdottir (2015) Dawson (2015) Innes (2015) Schroeder (2015) Simon (2015) Cajazeira (2014) Sharif (2014) Fron Chabouis (2013) Yengopal (2009)
	Remineralising technologies	3 Systematic reviews with moderate or low risk of bias Astvaldsdottir (2016) Raphael (2015) Yengopal (2009)		5 Systematic reviews with moderate or low risk of bias Fernandez-Ferrer (2018) Gao (2016) Raphael (2015) Li (2014) Chen (2013)
	Nonfluoride caries preventive measures and nonoperative treatment	10 Systematic reviews with moderate or low risk of bias Liang (2018) Skeie (2018) Wang (2017) Dorri (2015) Wierichs (2015) Chou (2013) Antonio (2011) Kaklamanos (2008) Robinson (2005) Sicilia (2002)	2 Systematic reviews with moderate or low risk of bias Lima (2018) Urquhart (2018)	11 Systematic reviews with moderate or low risk of bias Kalf-Scholte (2018) Janakiram (2017) Kumar (2016) Duangthip (2015) Riley (2015) Moynihan (2014) Papageorgiou (2013) Poklepovic (2013) Harris (2012) Sambunjak (2011) Van der Weijden (2011)
	Other areas	2 Systematic reviews with moderate or low risk of bias Cagetti (2018) Cooper (2013)		5 Systematic reviews with moderate or low risk of bias Gloria (2018) Smail-Faugeron (2018) Arora (2017) Gruner (2016) Senneby (2015)
	Not subgrouped due to high risk of bias	56 Systematic reviews with high risk of bias Chaudhary (2018) da Rosa (2018) Jobim Jardim (2017) Abdullah (2016) Masarwa (2016) Baroudi (2015) Domejean (2015) Gupta (2015) Hamama (2015) Kielbassa (2015) Li (2015) Maru (2015) Migliorati (2015) Twetman (2015) Twetman (2015) Grivas (2014) Opdam (2014) Cagetti (2013) Condo (2013) Tellez (2013) Kuhnisch (2012) Mickenautsch (2012) Twetman (2012) Bergstrand (2011) Kantovitz (2010) Mickenautsch (2010) Rogers (2010) Uzbelger Feldman (2010) Azarpazhooh (2009) Gooch (2009) Rosenblatt (2009) Azarpazhooh (2008) Azarpazhooh (2008) Azarpazhooh (2008) Azarpazhooh (2008) Azarpazhooh (2008) Deshpande (2008) Griffin (2008) Thompson (2008) Ammari (2007) Costa (2007) Mickenautsch (2007) Gunsolley (2006) Kolahi (2006) van 't Hof (2006) Zhang (2006) Alves (2005) Chadwick (2005) Jedel (2005) Axelsson (2004) Marinho (2003) Mejare (2003) Twetman (2003) Bader (2001) Clarkson (2001) McComb (2001)	10 Systematic reviews with high risk of bias Dye (2015) Gimenez (2015) Hickel (2013) Mickenautsch (2013) Gibson (2011) James (2010) Twetman (2008) Beiruti (2006) Bader (2004) Bader (2001)	64 Systematic reviews with high risk of bias Boutsiouki (2018) da Rosa (2018) dos Santos (2018) Garcia (2018) Giacaman (2018) Krois (2018) Mishra (2017) Ntovas (2017) Paula (2017) Rahimi (2017) Boruziniat (2016) do Amaral (2016) Domejean (2016) Horst (2016) Jorgensen (2016) Kielbassa (2016) Twetman (2016) Twetman (2016) Beck (2015) Demarco (2015) Gupta (2015) Heintze (2015) Ines Meurer (2015) Karpinski (2015) Lai (2015) Schwendicke (2015) de Assuncao (2014) Mejare (2014) Peumans (2014) Santos (2014) Talioti (2014) Zhu (2014) Bergenholtz (2013) Muller-Bolla (2013) Raggio (2013) Santos (2013) Schwendicke (2013) Sgolastra (2013) Chee (2012) de Amorim (2012) Ferreira (2012) Heintze (2012) Kemoli (2012) Mickenautsch (2012) Bergstrand (2011) Hayashi (2011) He (2011) Patel (2010) Kolavic Gray (2009) Mickenautsch (2009) Griffin (2007) Hujoel (2006) Bloemendal (2004) Derks (2004) Petersson (2004) Pinheiro (2004) Twetman (2004) Twetman (2004) Ammari (2003) Brunthaler (2003) Marinho (2003) Marinho (2003) Clarkson (2001) Hickel (2000)
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