Pseudobuldar affect is characterized by uncontrollable crying, laughter or other emotional displays. It can occur secondary to a neurological disorder or traumatic brain injury. The drug Nuedexta has been approved by the FDA in 2010 as a treatment option for pseudobulbar affect in patients with ALS or MS. However, in the EU Nuedexta has been deregistered since 2016 for market reasons according to the company. The question posed to the SBU Enquiry Service concerns what scientific studies that have documented the efficacy and safety of Nuedexta as a treatment of pseudobulbar affect in patients with ALS.
Are there scientific studies on efficacy and safety of the drug Nuedexta (dextrometorphan/quinidine) for symptomatic treatment of pseudobulbar affect in patients with ALS?
SBU Enquiry response consists of systematic literature searches to highlight studies that can address questions received by the SBU Enquiry Service from Swedish healthcare or social service providers. Relevant references are compiled by an SBU staff member, in consultation with an external expert when needed. The quality of the studies identified is not systematically reviewed.
Nathalie Peira och Sally Saad at SBU.